Home » Contacts » Kuan-Hui Chen

Kuan-Hui Chen

Math and Sciences

Asst Professor of Biology


  • Ph.D., University of California at Riverside, USA – Biomedical Sciences (2011)
  • M.S., National Cheng Kung University, Taiwan – Biotechnology (2003)
  • B.S., Tzu Chi University, Taiwan – Life Science (2002)

Courses taught

  • BIO 100. General Biology
  • BIO 427/BIO 527. Immunology
  • BIO 423/BIO 523. Histology
  • BIO 492. Cancer Biology

Research Interests

  • Impacts of endocrine hormones on tumor development
  • Epigenetic modification and regulation on tumor progression
  • Identification of therapeutic targets against tumor stem cells
  • Importance of hormones in tumor immunity
  • Sexual dimorphism in human biology such as perinatal development of immune system
  • Endocrine, immune and metabolism defects in obesity

Professional Organizations/Society

  • Endocrine Society
  • American Association for Cancer Research
  • American Association for Immunologists
  • Mississippi Academy of Sciences

Grants/Awards received

  • NIGMS Mississippi INBRE Developmental Grant [$338,889 (indirect cost $38,889. Direct cost $300,000)] 2020-2023
  • American Association for Immunologist Early Career Faculty Travel Grant 2019
  • California Breast Cancer Research Program (CBCRP) Innovative Developmental and Exploratory Award (IDEA) grant ($187,500) 2017-2019
  • California Breast Cancer Research Program Symposium Best Poster Presentation 2013
  • Tilton-Carr Cancer Research Award 2011
  • Endocrine Society Poster Presidential Presentation Award 2010
  • Cancer Federation Research Awards 2008, 2010


  • KuanHui E Chen, Ameae Walker. SPLICE MODULATING OLIGONUCLEOTIDES THAT INHIBIT CANCER. US Patent 9,909,128 (Granted), (World patent WO2014078749A1 pending)

Recent publications (Journals)

  • Kuan-Hui Ethan Chen*, Mrinal Ghosh, Lorena Rivera, Samuel Lin, Anil Kumar, Srividya Swaminathan, Mary Y. Lorenson, Ameae M. Walker*. Prolactin enhances T regulatory cell promotion of breast cancer through the long form prolactin receptor. Translational Oncology. Volume 14, Issue 11, November 2021, 101195. https://doi.org/10.1016/j.tranon.2021.101195  * correspondence
  • Chen KE*, Lainez NM*, Nair MG, Coss D. Visceral adipose tissue imparts peripheral macrophage influx into the hypothalamus. J Neuroinflammation. 2021 Jun 21;18(1):140. doi: 10.1186/s12974-021-02183-2. PubMed PMID: 34154608. * equal contribution
  • Ghosh MK*, Chen KE*, Dill-Garlow R, Ma LJ, Yonezawa T, Itoh Y, Rivera L, Radecki KC, Wu QP, Arnold AP, Muller HK, Walker AM. Sex Differences in the Immune System Become Evident in the Perinatal Period in the Four Core Genotypes Mouse. Front Endocrinol (Lausanne). 2021;12:582614. doi: 10.3389/fendo.2021.582614. eCollection 2021. PubMed PMID: 34122327; PubMed Central PMCID: PMC8191418. * equal contribution
  • Chen KE, Lainez NM, Coss D. Sex Differences in Macrophage Responses to Obesity-Mediated Changes Determine Migratory and Inflammatory Traits. J Immunol. 2021 Jan 1;206(1):141-153. doi: 10.4049/jimmunol.2000490. Epub 2020 Dec 2. PubMed PMID: 33268480.
  • Riva Dill-Garlow, KuanHui Ethan Chen and Ameae M. Walker. Sex Differences in Mouse Popliteal Lymph Nodes. Scientific Reports. 2019; 9: 965. DOI: 10.1038/s41598-018-37175-5. PubMed PMID: 30700819 PubMed Central PMCID: PMC6354021
  • Mary Y. Lorenson, KuanHui Ethan Chen, and Ameae M. Walker. Enzyme-Linked Oligonucleotide Hybridization Assay (ELOHA) for Direct Oligo Measurement in Blood. Biology Methods and Protocols, Volume 4, Issue 1, 1 January 2019, DOI: 10.1093/biomethods/bpy014, PubMed PMID: 32395619 PubMed Central PMCID: PMC7200967
  • Lopez T, Chuan C, Ramirez A, Chen KE, Lorenson MY, Benitez C, Mustafa Z, Pham H, Sanchez R, Walker AM, Ge X. Epitope-specific affinity maturation improved stability of potent protease inhibitory antibodies. Biotechnol Bioeng. 2018 Nov;115(11):2673-2682. doi: 10.1002/bit.26814. Epub 2018 Sep 15. PubMed PMID: 30102763; PubMed Central PMCID: PMC6202216.
  • Chen KE, Chen C, Lopez T, Radecki KC, Bustamante K, Lorenson MY, Ge X, Walker AM. Use of a novel camelid-inspired human antibody demonstrates the importance of MMP-14 to cancer stem cell function in the metastatic process. Oncotarget. 2018 Jun 29;9(50):29431-29444. doi: 10.18632/oncotarget.25654. eCollection 2018 Jun 29. PubMed PMID: 30034628; PubMed Central PMCID: PMC6047671.
  • Chen KE, Bustamante K, Nguyen V, Walker AM. Involvement of miR-106b in tumorigenic actions of both prolactin and estradiol. Oncotarget. 2017 May 30;8(22):36368-36382. doi: 10.18632/oncotarget.16755. PubMed PMID: 28422740; PubMed Central PMCID: PMC5482661.
  • Chen KE, Walker AM. Prolactin inhibits a major tumor-suppressive function of wild type BRCA1. Cancer Lett. 2016 Jun 1;375(2):293-302. doi: 10.1016/j.canlet.2016.03.007. Epub 2016 Mar 9. PubMed PMID: 26970274.
  • Chen KE, Walker AM. Emerging roles of prolactin-mediated BRCA1 function. Translational Cancer Research. 2016; doi: 10.21037/tcr.2016.08.43.
  • Yonezawa T, Chen KH, Ghosh MK, Rivera L, Dill R, Ma L, Villa PA, Kawaminami M, Walker AM. Anti-metastatic outcome of isoform-specific prolactin receptor targeting in breast cancer. Cancer Lett. 2015 Sep 28;366(1):84-92. doi: 10.1016/j.canlet.2015.06.010. Epub 2015 Jun 18. PubMed PMID: 26095602.Huang KT, Tan D, Chen KE, Walker AM. Blockade of estrogen-stimulated proliferation by a constitutively-active prolactin receptor having lower expression in invasive ductal carcinoma. Cancer Lett. 2015 Mar 28;358(2):152-160. doi: 10.1016/j.canlet.2014.12.031. Epub 2014 Dec 16. PubMed PMID: 25527452.
  • Tan D, Chen KE, Deng C, Tang P, Huang J, Mansour T, Luben RA, Walker AM. An N-terminal splice variant of human Stat5a that interacts with different transcription factors is the dominant form expressed in invasive ductal carcinoma. Cancer Lett. 2014 Apr 28;346(1):148-57. doi: 10.1016/j.canlet.2013.12.030. Epub 2013 Dec 30. PubMed PMID: 24384092; PubMed Central PMCID: PMC3959904.
  • Lorenson MY, Ueda EK, Chen KE, Walker AM. A major prolactin-binding complex on human milk fat globule membranes contains cyclophilins A and B: the complex is not the prolactin receptor. Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E585-94. doi: 10.1152/ajpendo.00480.2011. Epub 2011 Dec 28. PubMed PMID: 22205628.
  • Tan D, Chen KE, Khoo T, Walker AM. Prolactin increases survival and migration of ovarian cancer cells: importance of prolactin receptor type and therapeutic potential of S179D and G129R receptor antagonists. Cancer Lett. 2011 Nov 1;310(1):101-8. doi: 10.1016/j.canlet.2011.06.014. Epub 2011 Jun 25. PubMed PMID: 21775057.
  • Chen Y, Huang K, Chen KE, Walker AM. Prolactin and estradiol utilize distinct mechanisms to increase serine-118 phosphorylation and decrease levels of estrogen receptor alpha in T47D breast cancer cells. Breast Cancer Res Treat. 2010 Apr;120(2):369-77. doi: 10.1007/s10549-009-0400-7. Epub 2009 Apr 18. PubMed PMID: 19377875.
  • Deng C, Ueda E, Chen KE, Bula C, Norman AW, Luben RA, Walker AM. Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells. Mol Endocrinol. 2009 Feb;23(2):226-36. doi: 10.1210/me.2008-0075. Epub 2008 Dec 12. PubMed PMID: 19074549; PubMed Central PMCID: PMC5419306.


  • Chen KE, Walker AM. Potential Roles of miR-106a in Breast Cancer. In: Breast Cancer-Carcinogenesis, Cell Growth and Signaling Pathways. Gunduz M, editor. Online: InTech; 2011. Chapter 25; p.20. 523-542p.


  • Kuan-Hui Ethan Chen. MECHANISMS OF IMMUNE SUPPRESSION BY METASTATIC CANCER STEM CELLS. Mississippi Academy of Sciences 2021
  • Zaida Laventure, Kuan-Hui Ethan Chen. MODULATION OF MACROPHAGE PLASTICITY AND POLARIZATION BY CANCER STEM CELLS. Mississippi Academy of Sciences 2021
  • Kuan-Hui Ethan Chen and Ameae Walker. Metabolic Reprogramming of Arginine in Tumor Stem Cells Facilitates Immune Escape. (2019) The Journal of Immunology 202 (1 Supplement), 137.6-137.6.
  • Kuan-Hui Ethan Chen and Ameae Walker. Phenotypic change specific to tumor-infiltrating regulatory T cells by LFPRLR knockdown. Cancer Research 77(13 Supplement):LB-211-LB-211. 2017
  • Kuan-Hui Ethan Chen, Mrinal Ghosh, Tomohiro Yonezawa and Ameae Walker. Prolactin drives the recruitment of tumor Tregs and Treg-mediated metastasis. Cancer Research 74 (19 Supplement), LB-255-LB-255. 2014
  • *KuanHui E Chen, *Tomohiro Yonezawa, Mrinal Ghosh, Lorena Rivera, Riva Dill, David Duong and Ameae Walker. Antimaia : First in a new class of breast cancer therapeutics. CBCRP. 2013 (*Co-authorship)
  • *KuanHui E Chen, *Tomohiro Yonezawa, Mrinal Ghosh, Lorena Rivera, Riva Dill, David Duong and Ameae Walker. Cancer Research 73 (8 Supplement), 2444-2444 (2013) (*Co-authorship). 2013
  • KuanHui E Chen, Ameae Walker. Prolactin inactivates p21 by initiating phosphorylation by Pim-1 kinase and the retention of p21 in the cytosol. FASEB, 2012
  • KuanHui E Chen, Ameae Walker. Effects of Prolactin (PRL) and the Selective PRL Receptor Modulator, S179D PRL, on the BRCA1-p21 Axis in Breast, Ovarian, and Prostate Cancer Cell Lines. Endocrine Society, 2010.

Dr. Chen joined Delta State Aug. 2020

Division of Mathematics & Sciences